2019 Coronavirus Disease "COVID-19" [USA Surpasses China in Total Confirmed Cases]

Picasso

Picasso

Legendary Member
Orange Room Supporter
‘Brace Yourself’: Doctors in Italy Share Coronavirus Advice | NYT News

 
  • Advertisement
  • Picasso

    Picasso

    Legendary Member
    Orange Room Supporter
    Can You Become Immune to the Coronavirus?

    By Apoorva Mandavilli

    It’s likely you can, at least for some period of time. That is opening new opportunities for testing and treatment.

    As the number of people infected with the coronavirus surpasses 450,000 worldwide, and more than one billion are locked in their homes, scientists are wrestling with one of the most pressing questions of the pandemic: Do people who survive the infection become immune to the virus?

    The answer is a qualified yes, with some significant unknowns. That’s important for several reasons.

    People who are confirmed to be immune could venture from their homes and help shore up the work force until a vaccine becomes available, for example. In particular, health care workers who are known to be immune could continue to care for the severely ill.

    Growing immunity in the community also is the way the epidemic ends: With fewer and fewer people to infect, the coronavirus will lose its toehold and even the most vulnerable citizens become more insulated from the threat.

    Immunity may also bring an early treatment. Antibodies gathered from the bodies of those who have recovered may be used to aid those struggling with the illness caused by the coronavirus, called Covid-19.

    On Tuesday, the Food and Drug Administration approved the use of plasma from recovered patients to treat some severe cases. A day earlier, Gov. Andrew M. Cuomo announced that New York would become the first state to begin testing serum from people who have recovered from Covid-19 to treat those who are seriously ill.

    “It’s a trial for people who are in serious condition, but the New York State Department of Health has been working on this with some of New York’s best health care agencies, and we think it shows promise,” Mr. Cuomo said.

    The body’s first line of defense against an infectious virus is an antibody called immunoglobulin M, whose job is to stay vigilant in the body and alert the rest of the immune system to intruders like viruses and bacteria.

    Days into an infection, the immune system refines this antibody into a second type, called immunoglobulin G, exquisitely designed to recognize and neutralize a specific virus.

    The refinement may take as long as a week; both the process and the potency of the final antibodies can vary. Some people make powerful neutralizing antibodies to an infection, while others mount a milder response.

    The antibodies generated in response to infection with some viruses — polio or measles, for example — bestow a lifetime of immunity. But antibodies to the coronaviruses that cause the common cold persist for just one to three years — and that may be true of their new cousin as well.

    A study in macaques infected with the new coronavirus suggested that once infected, the monkeys produce neutralizing antibodies and resist further infection. But it is unclear how long the monkeys, or people infected with the virus, will remain immune.

    Most people who became infected during the SARS epidemic — that virus is a close cousin of the new coronavirus, called SARS-CoV-2 — had long-term immunity lasting eight to 10 years, said Vineet D. Menachery, a virologist at the University of Texas Medical Branch at Galveston.

    Those who recovered from MERS, another coronavirus, saw much shorter-term protection, Dr. Menachery said. People who have been infected with the new coronavirus may have immunity lasting at least one to two years, he added: “Beyond that, we can’t predict.”

    Still, even if antibody protection were short-lasting and people became reinfected, the second bout with the coronavirus would likely be much milder than the first, said Florian Krammer, a microbiologist at the Icahn School of Medicine at Mount Sinai in New York.

    Even after the body stops producing neutralizing antibodies, a subset of immune memory cells can reactivate a response effectively, he noted.

    “You probably would make a good immune response before you even become symptomatic again and might really blunt the course of the disease,” Dr. Krammer said.

    A crucial question is whether children and adults who have only mild symptoms still generate a strong enough response to remain immune to the virus until a vaccine is available.

    Dr. Marion Koopmans, a virologist at Erasmus University in Rotterdam, and her team have screened antibody responses in 15 infected patients and health care workers.

    The researchers are also using banked blood samples from about 100 people who were known to be infected with one of four coronaviruses known to cause the common cold.

    If those samples show some immune response to the new coronavirus, too, Dr. Koopmans said, it might explain why some people — children, for example — have only mild symptoms. They may have antibodies to related coronaviruses that are at least somewhat effective against the new one.

    The quickest way to assess immunity is a blood test that looks for protective antibodies in the blood of people who have recovered. But first you have to have the test.

    Antibody tests are used in Singapore, China and a handful of other countries. But they are just coming to market in much of the West.

    Last week, Dr. Krammer and his colleagues developed one such antibody test that could be scaled up in “days to weeks,” he said.

    The team validated the test in blood plasma taken from three patients with Covid-19. The researchers are seeking speedy approval from the F.D.A.

    Dozens of other labs are also at work on a dizzying list of tests, although they, too, are mostly based on slim data that has not yet been reviewed by other scientists.

    “No matter who makes them, as long as they’re reliable, that’s a super nice tool,” Dr. Krammer said. Because this is a new coronavirus, the test should deliver “basically, a yes or no answer, like an H.I.V. test — you can figure out who was exposed and who wasn’t.”

    On Wednesday, officials of Public Health England said they had purchased millions of newly developed antibody tests and were evaluating them for patients to use at home. Citizens who discovered they had been exposed and now had some immunity to the coronavirus might be able to return to normal lives, the officials said.

    That would be particularly useful for health care workers. Those who know they have at least some immunity could be placed on the front lines of emergency care, sparing colleagues who have not been exposed.

    “If this really goes on for months at a time, for 18 months as some people have projected, having health care workers who are immune to the virus will be really, really helpful,” said Angela Rasmussen, a virologist at Columbia University in New York.

    But tests like these may not be of much use for diagnosis of coronavirus infection as it gets underway, because of the time it takes for the body to begin producing antibodies.

    Dr. Krammer’s test picks up an antibody response as early as three days after symptoms emerge. Given that people may not show symptoms for as long as 14 days after infection, however, that is too late for the test to be useful as a diagnostic tool.

    Finding people with powerful antibody responses might help point the way to new treatments, however. Essentially, antibodies extracted from the blood of recovered patients are injected into those who are ill.

    Several teams have already been working on such an effort, following early reports from China of success. A Beijing-based company called AnyGo Technology has provided 50,000 tests to the Chinese Center for Disease Control and Prevention, and to hospitals in Wuhan, Beijing and Shanghai, according to its founder, Dr. Le Sun.

    Dr. Shangen Zheng, a doctor with the Chinese military, said his team had treated more than 10 patients so far, and data from many more patients treated with plasma in Hubei Province is being assessed.

    This approach is actually “something very old-fashioned,” Dr. Krammer said. It was used to save American soldiers infected with the hemorrhagic Hantaan virus during the Korean War, and to treat people in Argentina infected with the hemorrhagic Junin virus.

    Before the method can be put into wide use, however, scientists must work out safety issues, such as ensuring that the plasma taken from recovered patients is free of other viruses and toxins.

    Pharmaceutical companies like Takeda and Regeneron are hoping to sidestep some of those questions by developing antibodies against the coronavirus in the laboratory.

    Ultimately, it is only with these tests that scientists will be able to say when enough of the population has been infected and has become immune — and when the virus has begun to run out of hosts.


    NYTimes
     
    Abou Sandal

    Abou Sandal

    Legendary Member
    Orange Room Supporter
    White House Pushes U.S. Officials to Criticize China For Coronavirus ‘Cover-Up’

    A State Department cable obtained by The Daily Beast says the U.S. and the American people are the “greatest humanitarians the world has ever known.”
    Published Mar. 21, 2020


    As the number of coronavirus cases continues to grow at a rapid pace in the U.S., the White House is launching a communications plan across multiple federal agencies that focuses on accusing Beijing of orchestrating a “cover-up” and creating a global pandemic, according to two U.S. officials and a government cable obtained by The Daily Beast.

    The cable, sent to State Department officials Friday, lays out in detail the circumstances on the ground in China, including data on coronavirus cases and deaths, the local business environment and transportation restrictions. But it also issues guidelines for how U.S. officials should answer questions on, or speak about, the coronavirus and the White House’s response in relation to China.

    The talking points appear to have originated in the National Security Council. One section of the cable reads “NSC Top Lines: [People’s Republic of China] Propaganda and Disinformation on the Wuhan Virus Pandemic.”

    “Chinese Communist Party officials in Wuhan and Beijing had a special responsibility to inform the Chinese people and the world of the threat, since they were the first to learn of it,” the cable reads.Instead, the... government hid news of the virus from its own people for weeks, while suppressing information and punishing doctors and journalists who raised the alarm. The Party cared more about its reputation than its own people’s suffering.”

    The cable was disseminated to officials at a time when the administration is engrossed in a communications battle around how to disseminate the flow of crucial health information to the American public while at the same time deflecting criticism that the White House was unprepared for the pandemic and that President Trump is at odds with members of his coronavirus task force.

    One of the results of those internal deliberations appears to be a renewed focus on underscoring China’s missteps. Two U.S. officials working on the administration’s coronavirus response said the White House is pushing federal agencies to stick closely to the national security council’s talking points, especially when senior officials take to the podium, to ensure continuity with President Trump.

    “These talking points are all anyone is really talking about right now,” one official said. “Everything is about China. We’re being told to try and get this messaging out in any way possible, including press conferences and television appearances.”

    The White House did not immediately respond to a request for comment.

    Over the last several weeks top administration officials, including President Trump and Secretary of State Mike Pompeo have referred to the coronavirus as both the “Chinese virus” and the “Wuhan virus.” Beijing’s leaders have pushed back on the designation, claiming the terms are xenophobic and inaccurate now that the virus has spread to dozens of countries across the world. American doctors and scientists involved with the administration’s task force operations continue to call it “the coronavirus.”

    “The [Chinese Communist Party] is waging a propaganda campaign to desperately try to shift responsibility for the global pandemic to the United States. This effort is futile,” one of the talking points in the cable reads. “Thanks to the… cover-up, Chinese and international experts missed a critical window to contain the outbreak within China and stop its global spread. Saving lives is more important than saving face.”

    But the administration isn’t just focusing on criticizing China, it’s also painting America’s response to the global pandemic as “extraordinary humanitarianism”.

    “The United States and the American people are demonstrating once again that they are the greatest humanitarians the world has ever known,”
    according to the cable. “The United States stands ready to provide more assistance to China, if the Chinese Communist Party would allow us to do so.”

    The cable notes that the U.S. has donated millions of dollars worth of medical supplies and provided financial assistance for countries trying to fight the coronavirus.

    As of last week, about “95 percent of China’s cities and prefectures had reported zero new cases in the past 14 consecutive days as of March 19, including 16 of the 17 prefectures and cities in Hubei Province,” according to the cable, which noted that the State Department had conducted an analysis of the data.

    “Cases among Chinese travelers infected in other countries accounted for virtually all the new cases reported outside Hubei since March 13,” according to the cable. “While the vast majority of these cases are Chinese nationals, the first confirmed imported case of a U.S. citizen was reported in the Shanghai consular district.”

    Meanwhile, in the U.S., the number of positive coronavirus cases ticked above the 20,000 mark Saturday morning, with more than 270 deaths reported.



     
    TayyarBeino

    TayyarBeino

    Legendary Member




    مقررات المجلس الاعلى للدفاع:
    - الرئيس عون عرض للتدابير والإجراءات التي اتخذت وشدّد على أهمية التمييز بين إعلان التعبئة العامة وحال الطوارئ ودياب أكد أهمية الوصول إلى نسبة عالية من الإلتزام
    - اطلع رئيس الحكومة المعنيين على توصية اللجنة المعنية متابعة الاجراءات للحد من انتشار "كورونا" والتي قضت بتمديد التعبئة العامة لأسبوعين
    - تمديد التعبئة العامة لغاية 12 نيسان 2020 ولضرورة الالتزام بالبقاء في المنازل
    - تم عرض معاناة اللبنانيين الموجودين في الخارج كما تم عرض معطيات حول الوباء وسبل التعاطي معه
     
    TayyarBeino

    TayyarBeino

    Legendary Member
    11:55
    الحكومة الهندية تخصص 22.6 مليار دولار لمساعدة الفئات الأشد تضررا من عملية الإغلاق الكامل بسبب فيروس كورونا
    11:51
    إيران - تسجيل 157 وفاة و 2389 اصابة بالكورونا اليوم
     
    AtheistForJesus

    AtheistForJesus

    Legendary Member
    Orange Room Supporter






    مقررات المجلس الاعلى للدفاع:
    - الرئيس عون عرض للتدابير والإجراءات التي اتخذت وشدّد على أهمية التمييز بين إعلان التعبئة العامة وحال الطوارئ ودياب أكد أهمية الوصول إلى نسبة عالية من الإلتزام
    - اطلع رئيس الحكومة المعنيين على توصية اللجنة المعنية متابعة الاجراءات للحد من انتشار "كورونا" والتي قضت بتمديد التعبئة العامة لأسبوعين
    - تمديد التعبئة العامة لغاية 12 نيسان 2020 ولضرورة الالتزام بالبقاء في المنازل
    - تم عرض معاناة اللبنانيين الموجودين في الخارج كما تم عرض معطيات حول الوباء وسبل التعاطي معه
    Is this official? They'll extend the lockdown till April 12?
     
    AtheistForJesus

    AtheistForJesus

    Legendary Member
    Orange Room Supporter
    Israel, Norway, Czech republic and others have incredibly low death rates:

    Israel 2,495 cases, 5 deaths
    Czech Republic 1,775, 6 deaths
    Saudi Arabia 900 cases, 2 deaths
    Chile 1,142 cases, 3 deaths
    Thailand 1,045 case, 4 deaths
    Australia, 2,805, 13 deatjs
    Norway 3,185, 14 deaths
     
    TayyarBeino

    TayyarBeino

    Legendary Member



    12:27

    الكرملين يدعو للاستعداد لأسوأ سيناريو بالتزامن مع إطلاق تدابير إغلاق واسعة في موسكو بسبب كورونا
     
    Top